Efecto gastroprotector de extractos de centaurea calcitrapa

  • Mirta Susana Toribio UNLPam Facultad de Ciencias Veterinarias
  • Ricardo Enrique Toso UNLPam. Facultad de Ciencias Veterinarias
  • Mario Ignacio Skliar UNS

Keywords:

Asteraceae, Centaurea calcitrapa, Flavonoids, gastroprotection

Abstract

The gastroprotective activity of dried heads of Centaurea calcitrapa was studied in mice in whom ulcers had been caused by subjecting them to stress for hypothermia and immobilization. A group of five mice used as control, was administered a mixture of Tween 80 and carboxymethylcellulose by oral via Other three groups, of equal number of animals, and using the same administration via, were treated with aqueous, methanolic and chloroformic extracts resuspended in a mixture of the excipients. The aqueous and methanolic extracts of dry heads of Centauea calcitrapa prevented 100% the damage on the gastric mucosa and the chloroformic extracts inhibited 96.4% (P0.01). These results evidence the metabolites presence with gastroprotective activity in Centaurea calcitrapa

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Author Biographies

Ricardo Enrique Toso, UNLPam. Facultad de Ciencias Veterinarias

Formación en Farmacología. Dirige el Centro de Invest. y Desarrollo de Fármacos (CIDEF) de la FCV-UNLPam donde participa en el desarrollo de trab. de invest .Desarrollo protocolos de extracción de compuestos vegetales y ensayos para determinar su bioactividad utilizando mod. in vivo e in vitro

Mario Ignacio Skliar, UNS

DPTO. BIOLOGIA, BIOQUIMICA Y FARMACIA

Published

2017-09-22

How to Cite

Toribio, M. S., Toso, R. E., & Skliar, M. I. (2017). Efecto gastroprotector de extractos de centaurea calcitrapa. Ciencia Veterinaria, 5(1), 34–37. Retrieved from https://ojs.unlpam.edu.ar/ojs/index.php/veterinaria/article/view/1958

Issue

Section

Artículos de Investigación