Comparative study of tne immunogenic capacity of two adjuvant used in equine influenza vaccine

  • Jose Luis Montenegro UNLPam. Facultad de Cs. Veterinarias
  • Marcelo Fabián Gastaldo UNLPam. Facultad de Ciencias Veterinarias
  • Nicolás María José Alvarez Rubianes
  • Guillermo ESteban Meglia UNLPam. Facultad de Cs. Veterinarias
  • Juan Manuel Montenegro

Keywords:

Vaccine, Adjuvant, Equine influenza

Abstract

Inactivated vaccines of national production, for use in the equine, carried mostly in its formulation as an adjuvant, aluminum hydroxide Al(OH)3. Nowadays there are new adjuvants potentially superior to the traditional, either with respect to an increase in the time of permanence of the antigen in the host, and the immune response that induce. In the present work was compared the action of adjuvant Emulsigen respect aluminum hydroxide, which were used in a vaccine against equine influenza. For this purpose were established two test models, horses and guinea pigs, and the immune response induced was assessed by means of the determination of antibody titers. The results showed higher titers and extended serum antibodies persistence with the vaccine adjuvanted with Emulsigen, in relation to that adjuvanted with Al(OH)3, likewise were not observed adverse reaction in the site of inoculation.

Downloads

Download data is not yet available.

Author Biographies

Jose Luis Montenegro, UNLPam. Facultad de Cs. Veterinarias

Docente en la  cátedra de Microbiología General e Inmunología Básica. Trabajos de investigación con virus de abejas (sustrato celular de larvas de Apis melífera) en forma conjunta con INTA Castelar

Guillermo ESteban Meglia, UNLPam. Facultad de Cs. Veterinarias

Desarrollo la actividad científica en el campo de la medicina preventiva veterinaria. La línea de investigación radica básicamente en dos grandes áreas, una relacionada con la brucelosis en rumiantes y la otra, en el efecto de los antioxidantes sobre la actividad del sistema inmunitario

Published

2017-07-31

How to Cite

Montenegro, J. L., Gastaldo, M. F., Alvarez Rubianes, N. M. J., Meglia, G. E., & Montenegro, J. M. (2017). Comparative study of tne immunogenic capacity of two adjuvant used in equine influenza vaccine. Ciencia Veterinaria, 14(1), 68–74. Retrieved from https://ojs.unlpam.edu.ar/ojs/index.php/veterinaria/article/view/1844

Issue

Section

Artículos de Investigación