Experimental model to evaluate the gastrointestinal transit in mice

  • Ricardo Enrique Toso UNLPam
  • Mario Skliar UNS
  • Edgardo Verna UNLPam. Facultad de Ciencias Veterinarias

Keywords:

Gastrointestinal motility, experimental model

Abstract

An experimental model is described to evaluate drug action, medicinal formulations or vegetable extracts on gastrointestinal transit. Test compounds are administered to 4 mice, 30 minutes before beginning the bioessay to assure the absorption. Immediately before the essay, a per os barium sulfate solution is given and serial radiographies are taken every 30 minutes. Observing the progress of the radiopaque substance in the gastrointestinal tract, it is possible to evaluate the action of different compounds among them or with respect to a control group. This method has advantages on some others already described, since it is bloodless, reproducible, reliable and economic. These characteristics allow their regular use to detect compounds that evidence a promissory pharmacological activity

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Author Biographies

Ricardo Enrique Toso, UNLPam

Formación en Farmacología. Dirige el Centro de Invest. y Desarrollo de Fármacos (CIDEF) de la FCV-UNLPam donde participa en el desarrollo de trab. de invest .Desarrollo protocolos de extracción de compuestos vegetales y ensayos para determinar su bioactividad utilizando mod. in vivo e in vitro

Mario Skliar, UNS

Cátedra de Farmacognosia, Depto. de Biología, Bioquímica y Farmacia, Universidad  Nacional del Sur, San Juan 670, (8000) Bahía Blanca

Edgardo Verna, UNLPam. Facultad de Ciencias Veterinarias

Docente Investigador.  Técnica  y Patología Quirúrgica. Trabajo  orientado hacia el diagnostico por imàgenes, radiología y ecografía. Práctica diaria en caballos deportivos y pequeños animales

Published

2017-09-22

How to Cite

Toso, R. E., Skliar, M., & Verna, E. (2017). Experimental model to evaluate the gastrointestinal transit in mice. Ciencia Veterinaria, 4(1), 44–48. Retrieved from https://ojs.unlpam.edu.ar/index.php/veterinaria/article/view/1967

Issue

Section

Artículos de Investigación