Gastroprotective effect of Equisetum giganteun (Cola de caballo) and Cortaderia selloana (Cortadera) in rats

  • Federico Toso UNLPam. Facultad de Ciencias Veterinarias Centro de Investigación y Desarrollo de Fármacos (CIDEF), Facultad de Ciencias Veterinarias, UNLPam. Calle 116 y 5. General Pico, La Pampa (6360).
  • Hebe Lina Alvarez Centro de Investigación y Desarrollo de Fármacos (CIDEF), Facultad de Ciencias Veterinarias, UNLPam. Calle 116 y 5. General Pico, La Pampa (6360).
  • Yolanda Mabel Marrón UNLPam. Facultad de Cs. Veterinarias Centro de Investigación y Desarrollo de Fármacos (CIDEF), Facultad de Ciencias Veterinarias, UNLPam. Calle 116 y 5. General Pico, La Pampa (6360).
  • Ricardo Enrique Toso UNLPam. Facultad de Ciencias Veterinarias Centro de Investigación y Desarrollo de Fármacos (CIDEF), Facultad de Ciencias Veterinarias, UNLPam. Calle 116 y 5. General Pico, La Pampa (6360).

Keywords:

vegetable extracts, farmacognosy, gastroprotective, cytoprotective

Abstract

The gastroprotective effect of two plants of La Pampa province Equisetum giganteun L. and Cortaderiaselloana (Schult&Schult. f.) were utilised in an ulcer incited model by hypothermia and immobilisation in rats. Aerial parts of the plants were dried in a heater by air flow at 60 °C. The vegetable drug was extracted by ethanol:water solvent (1:1, v/v). The Mus musculus rats were allotted in groups of five animals each. The observer group (OG) received an oral dose of 0,5 ml of excipient (Ex) composed by carboxymethylcellulose and tween 80 (1:1, v/v). The control group (CG) received 0,05 mg/kg of atropine subcutaneously and 0,5 ml of Ex orally, by contrast, the treated groups (GTEg and GTCs) received an oral dose of 1 gram hydro-alcoholic extract. The results, of both control and treatments groups, were com­pared and analysed with the results of the observed group by the student t-test. The atropine administered to the CG preven­ted the ulcer formation in all animals group. The two evaluated plants showed significant gastroprotective effect (p≤0,01) in re­lation to the CG. It concluded that the extract of the evaluated plants prevented the ulcer formation induced by stress in rats.

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Author Biographies

Hebe Lina Alvarez, Centro de Investigación y Desarrollo de Fármacos (CIDEF), Facultad de Ciencias Veterinarias, UNLPam. Calle 116 y 5. General Pico, La Pampa (6360).

Centro de Investigación y Desarrollo de Fármacos (CIDEF), Facultad de Ciencias
Veterinarias, UNLPam. Calle 116 y 5. General Pico, La Pampa (6360).

Becaria Posgrado CONICET

Ricardo Enrique Toso, UNLPam. Facultad de Ciencias Veterinarias Centro de Investigación y Desarrollo de Fármacos (CIDEF), Facultad de Ciencias Veterinarias, UNLPam. Calle 116 y 5. General Pico, La Pampa (6360).

Formación en Farmacología. Dirige el Centro de Invest. y Desarrollo de Fármacos (CIDEF) de la FCV-UNLPam donde participa en el desarrollo de trab. de invest .Desarrollo protocolos de extracción de compuestos vegetales y ensayos para determinar su bioactividad utilizando mod. in vivo e in vitro

Published

2017-08-08

How to Cite

Toso, F., Alvarez, H. L., Marrón, Y. M., & Toso, R. E. (2017). Gastroprotective effect of Equisetum giganteun (Cola de caballo) and Cortaderia selloana (Cortadera) in rats. Ciencia Veterinaria, 18(1), 29–38. Retrieved from https://ojs.unlpam.edu.ar/index.php/veterinaria/article/view/1896

Issue

Section

Artículos de Investigación